Dr Alec Redwood

DR ALEC REDWOOD

PRINCIPAL RESEARCH FELLOW
BAPPSCI PHD

Associate Professor Alec Redwood holds a B.Sc. (Hon) and PhD in immunology.  He has a focus on vaccine design, virus/host interactions and T-cell immunity, with a particular focus on antigen discovery.  Dr Redwood holds a number of international and national competitive grants and patents. He has extensive experience in vaccine design, specifically the use of cytomegalovirus (CMV) as a vaccine vector.  He led a large research team at the University of Western Australia’s (UWA) node of the Pest Animal Control-Cooperative Research Centre (PAC-CRC) applying disseminating CMV vectors to sterilise invasive pest species. These proof of concept studies were amongst the first to demonstrate the utility of CMVs as highly effective vaccine vectors.  CMV is now being trialled as a vaccine vector for a range of diseases including, HIV, Ebola and cancer. Dr Redwood pioneered the investigation of MCMV genomics and has sequenced, annotated and characterised 10 of the 12 murine CMV (MCMV) strains present in DNA databases. He now heads the Viral Genomics Group (VGG) at the Institute of Respiratory Health at UWA. The VGG is funded by US Department of Defense Advanced Research Projects Agency (DARPA) to use CMV as disseminating vectors for the control of zoonotic infectious agents, such as COVID-19 and Lassa Fever.  Dr Redwood also heads the neo-antigen and immune monitoring team at the National Centre of Asbestos Related Diseases (NCARD). This research seeks to develop therapeutic anti-cancer vaccines targeting expressed tumour specific mutations.

CURRENT PROJECTS

  • Improving Mesothelioma Therapy by Boosting Immune Responses to Mutations by Vaccination and by Immunogenic Chemotherapy.  Funding body: USA, Department of Defense (DoD) PI: Prof. Bruce Robinson. Co-PIs Prof. Jenette Creaney and Associate Prof. Alec Redwood.
  • Prediction of Spillover Potential and Interventional En Masse Animal Vaccination to Prevent Emerging Pathogen Threats in Current and Future Zones of US Military Operation (PREEMPT). Funding body: Defense Advanced Research Projects Agency (DARPA). Subaward Assoc. Prof. Alec Redwood.
  • Chief Investigators: Dr Peter Barry, Dr Michael Jarvis, Dr Brian Bird and Dr Scott Nuismer.  Co-investigators, Dr Alec Redwood, Dr Wolfram Brune, Dr Andrew Davison and Dr Heinz Feldmann.
  • Tissue specific T cells mediate drug hypersensitivity. Funding body: NH&MRC APP1123499. Chief Investigators: Professor Elizabeth Phillips, Professor Simon Mallal, Professor Ian James, Associate Professor Alec Redwood and Associate Professor Lloyd D’Orsogna.

RECENT HIGHLIGHTS

  • Jessica Boulter just awarded an Australian Government RTP and UWA – UPA award for her PhD.
  • PhD student Anuradha Sooda just awarded her PhD (Murdoch University).

RECENT PUBLICATIONS

  • Rebecca Pavlos, Pooja Deshpande, Abha Chopra, Shay Leary, Kaija Strautins, David Nolan, David Thorborn, Mark Shaefer, Andri Rauch, David Dunn, Julio Montaner, Anita Rachlis, Coral-Ann Almeida, Mrs Linda Choo, Dr Ian James, Alec Redwood, Yueran Li, Silvana Gaudieri, Simon Mallal, Elizabeth Phillips. 2020. New Genetic Predictors for Abacavir Tolerance in HLA-B*57:01 Positive Individuals. Human Immunology. 81(6). 300-304. PMID: 32173028.
  • Yunis, J., Redwood, A., Belz, G, and Stevenson, P. 2020. Membrane association of a model CD4+ T cell vaccine antigen confers enhanced yet incomplete protection against Murid Herpesvirus-4 infection.  Immunology and Cell Biology. 98(4):332-343. PMID: 31997396.
  • Redwood, A.J., Rwandamuriye, R., Chopra, A., Leary, S., Ram, R., McDonnell, W., Konvinse, K., White, K., Pavlos, R., Koelle, D.M., Mallal, S and Phillips, E.  2019. Single cell transcriptomics reveal polyclonal memory T-cell responses in abacavir patch test positive skin. Journal of Allergy Clinical Immunology. 144(5). 1413-1416.e7. PMID 31574267.
  • Helen Farrel, Kimberley Bruce, Alec Redwood and Philip Stevenson. 2019. Murine Cytomegalovirus disseminates independently of CX3CR1, CCL2 or its m131/m129 chemokine homologue. Journal of General Virology. 100:1695–1700. PMID: 31609196.
  • Jelena Železnjak, Vanda Juranić Lisnić, Branka Popović, Berislav Lisnić, Marina Babić Čač, Anne Halenius, Hartmut Hengel, Alec J. Redwood, Silvia M. Vidal, Lars Dölken, Astrid Krmpotić, Stipan Jonjić. 2019. The complex of MCMV proteins and MHC class I evades NK cell control via missing-self and drives the evolution of virus-specific activating Ly49 receptors. Journal of Experimental Medicine. 216(8), 1809-1827.
    PMID:31142589.
  • Konvinse, Katherine C., Trubiano, Jason A., Pavlos, Rebecca, James, Ian, Shaffer, Christian M., Bejan, Cosmin A., Schutte, Ryan J., Ostrov, David A., Pilkinton, Mark A., Rosenbach, Misha, Zwerner, Jeffrey P., Williams, Kristina B., Bourke, Jack, Martinez, Patricia, Rwandamuriye, Francois, Chopra, Abha, Watson, Mark, Redwood, Alec J. White, Katie D., Mallal, Simon A., Phillips, Elizabeth J. 2019. HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms. Journal of Allergy Clinical Immunology. 144(1):183-192. PMID:30776417.
  • Jason H Karnes, Matthew A. Miller, Katie D White, Katherine Konvinse, Rebecca Pavlos, Alec J Redwood, Jonny Peter, Rannakoe J Lehloenya, Simon Mallal and Elizabeth J Phillips. 2018.  Applications of Immunopharmacogenomics: Predicting, preventing, and understanding immune-mediated adverse drug reactions. 59. 463-486. Annual Review of Pharmacology and Toxicology. PMID: 30134124.
  • Kaitlyn M. Morabito, Tracy J. Ruckwardt, Erez Bar-Haim, Deepika Nair, Syed M. Moin, Alec J. Redwood, David A. Price and Barney S. Graham. 2018. Memory inflation drives tissue-resident memory CD8+ T cell maintenance in the lung after intranasal vaccination with MCMV. Frontiers in Immunology. 9 (1861). PMID: 30154789.
  • Arnaud Delpoux, Rodrigo Hess Michelini, Shilpi Verma, Chen-Yen Lai, Kyla D. Omilusik1, Alec J. Redwood, Christopher A. Benedict and Stephen M. Hedrick. 2017. Continuous Activity of FOXO1 Required for the Survival, Functionality, and Differentiation State of CD8+ T Cells. Journal of Experimental Medicine. 215 (2): 575-594. PMID: 29282254.
  • Alec J. Redwood, Rebecca K. Pavlos, Katie D. White, Elizabeth J. Phillips.  2017. HLAs: key regulators of T-cell mediated drug hypersensitivity. HLA. 91(1):3-16. PMID: 29171940.
  • White, K., Abe, R., Ardern-Jones, M., Beachkofsky, T., Bouchard, C., Carleton, B.,
    Chodosh, J.,  Cibotti, R., Davis, R., Denny, J., Dodiuk-Gad, R., Ergen, E., Goldman, J., Holmes, J., IV Hung, S., Lacouture, M., Lehloenya, R., Mallal, S., Manolio, T., Micheletti, R., Mitchell, C., Mockenhaupt, M., Ostrov, D., Pavlos, R., Pirmohamed, M., Pope, E., Redwood, A., Rosenbach, M., Rosenblum, M., Roujeau, J-C., Saavedra, A., Saeed, H., Struewing, J.,  Sueki, H., Sukasem, C., Sung, C., Trubiano, J., Weintraub, J., Wheatley, L., Williams, K., Worley, B., Chung, W-H., Shear, N. and Phillips, E.  2017. SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation. JACI: In Practice. 6(1):38-69. PMID: 29310768.
  • Trubiano, J.A., Strautins, K., Redwood, A., Pavlos, R., Konvinse KC., and Aung A, Slavin M. A., Thursky K. A., Grayson M. L., and Phillips E. J. (2017). The combined utility of ex vivo IFN-g release Enzyme Linked ImmunoSpot (ELISpot) and in vivo skin testing in patients with antibiotic-associated Severe Cutaneous Adverse Reactions. JACI: In Practice. S2213-2198(17):30728-6. PMID: 29100867.
  • Pavlos, R., McKinnon, E.J., Ostrov, D. A., Peters, B., Buus, S., Koelle, D., Chopra, A., Schutte, R. Rive, C., Redwood, A., Restrepo, S., Bracey, A., Kaever, T., Myers, P., Speers, E., Malaker, S.A., Shabanowitz, J., Yuan, J., Gaudieri, S., Hunt, D.F., Carrington, M., Haas, D.W., Mallal, S. and Phillips, E.J. (2017). Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles. Scientific Reports, 7(1): 8653. PMID: 28819312.
  • Trubiano, J.A., Redwood, A., Strautins, K., Pavlos, R., Woolnough. E., Chang, C.C. and Phillips, E. (2017). Drug specific upregulation of CD137+ on CD8+ T cells aids in the diagnosis of multiple antibiotic toxic epidermal necrolysis. JACI in Practice. 5(3): 823–826. PMID: 27888029.
  • Gimeno Brias, S., Stack, G., Stacey, M.A., Redwood, A.J. and Humphries, I.R. (2016). The role of IL-22 in viral infections: paradigms and paradoxes. Frontiers in Immunology 7: 211. PMID: 27303405.
  • Morabito, K.M., Ruckwardt, T.R., Redwood, A.J., Moin, S.M., Price, D.A. and Graham, B.S. (2016). Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung. Mucosal Immunology. 10(2):545-554. PMID: 27220815.
  • Jing L., Laing, KJ · Dong, L., Russell R.M., Barlow, R.S, Haas, J.G. Ramchandani, M.S., Johnston, C., Buss, S., Redwood, A.J., White, K. D., Mallal, S.A., Phillips, E.J., Posavad, C.M., Wald, A and Koelle, D.M (2016).  Extensive CD4 and CD8 T cell cross-reactivity between alphaherpesviruses. The Journal of Immunology. 196(5):2205-18. PMID: 26810224.
  • Murphy, A., Redwood, A.J. and Jarvis, M. (2016). Self-disseminating vaccines for emerging infectious diseases. Expert Review of Vaccines. 15(1):31-9. PMID: 26524478.
  • McWhorter, A., Smith, L., Shellam, G., Redwood, A.J. (2015), MCMV strains co-replicate at multiple tissue sites and establish co-persistence in salivary glands in the absence of Ly49H-mediated competition, Journal of General Virology, 96(5) 1127-37. PMID: 25575707.

Book Chapters

  • White K.D., Konvinse K, Lehloenya R, Redwood A, Phillips EJ. 2018. Chapter 4 – Immune Mechanisms of Drug Allergy A2 – Khan, David A, p 27-38. In Banerji A (ed), Drug Allergy Testing doi:https://doi.org/10.1016/B978-0-323-48551-7.00004-3. Elsevier.

Published Commentaries

  • Pavlos R, Redwood A, Phillips E.  AdDRESSing T-cell responses to anti-tuberculous drugs.  British Journal of Dermatology.  2017. 176(2), 292-293.

Editorials

  • Redwood, A., Trubiano, J. and Phillips, E. J. 2019. Prevention and Diagnosis of Severe T-Cell-Mediated Adverse Drug Reactions: Are We There Yet? JACI: In Practice. 7(1) 228-230.

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